Can FoxO1 and Sox2 TRANSCRIPTION FACTORS HELP IN PREDICTING PREECLAMPSIA!
Abstract
Preeclampsia (PE) is a multisystem pregnancy disorder that affects about 10 million women worldwide. It is significantly associated with pregnancy-related fetal and maternal morbidity and mortality. PE has been linked to an increased risk of cardiovascular disease in women later in life too. Determining the exact etiology of PE has proved to be a hard task. So, it is critical to demonstrate how the gene regulatory mechanisms may help as therapeutic targets and diagnosis of PE. We assessed the expression level of FoxO1 and Sox2 transcription factors in sera of PE cases compared to control group. FoxO1 and Sox2 were estimated in all subjects using real time PCR technique, acting on mRNA of FoxO1 and Sox2 as a starting material in serum. Both FoxO1 and Sox2 showed decreased expression level in PE group than the control group. Each of them showed an inverse association with the increased preceding abortion numbers among the PE patients. Sensitivity and specificity of both FoxO1 and Sox2 for predicting PE were assessed by applying receiver operating characteristic (ROC) curve analysis; FoxO2 showed more sensitivity and specificity than Sox2 in predicting PE in women at risk. FoxO1 and Sox2 seem to play a critical role in PE pathogenesis. Our results suggest that FoxO1 and Sox2 might be promising predicting and/ or diagnostic molecular biomarkers for PE.
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