GENOTOXICITY OF PATULIN IN BONE MARROW CELLS OF NEWLY BORN RATS

Authors

  • FAWZEYA A. ZAYED Zoology Department, Faculty of Science, Zagazig University, Zagazig
  • M. A. RASHED Genetic Department, Faculty of Agriculture, Ain Shames University, Cairo
  • SABHA E. ELBALLAT Zoology Department, Faculty of Science, Zagazig University, Zagazig
  • HASANATE E. ALI Zoology Department, Faculty of Science, Zagazig University, Zagazig

Abstract

Patulin is a toxin generated by many kinds of fungi as Penicillium. It is a known contaminant of ripe fruits especial- ly ripe apples. Patulin may be mutagenic, cytotoxic, teratogenic and clastogenic agent. Thus, the present work was aimed to evaluate the possible genotoxic effect (chromosomal aberrations) that may be induced by patulin (0.002 mg/kg b. w.) in the bone marrow cells of the newly born rats after oral injection of patulin to both of their parents. The results concluded that, patulin elicited a significant increase in total chromosomal aberrations (numeri- cal and structural) in the bone marrow cells of these rats babies.

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Published

2019-08-04

Issue

Vol. 48 No. 1 (2019)

Section

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