This study presented important data about the gap between serology screening (surface antigen) and nucleic acid testing (NAT) testing of blood donors. Effectiveness of NAT for blood donors screening is a debating area in blood transfusion. This study highlight on the riskiness of transfuse blood contain integrated HBV DNA owing to the carcinogenic effect of integrated HBV in human liver. Wide-national study is required to ensure blood transfusion safety and effectiveness by using traditional (surface antigen, core antigen as a serological test) confirmed by NAT testing to screen blood donors and introduce new techniques for the detection of viral integrated with the human genome.

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