Polymorphisms in cytokine genes responsible for inflammatory and immune responses are associated with risk of hepatocellular carcinoma (HCC) in Egyptian population. HCC study had conducted on 75 HCC patients and 75 matched control subjects of Egyptian population. Genetic variants in the IL-101082, TNF-α308 and IL-1β511 genes were analyzed by SNP. The logistic regression method was used to analyze the data, relative to the putative high-activity genotypes; individual low-activity genotypes were associated with statistically non-significant increases in HCC risk. The genotypic frequencies in the cases were not similar to that of the controls, TNF-α308 differences being statistically significant (P = 0.001). Using the GG genotype as the reference genotype, AA was significantly associated with increased risk of HCC (adjusted OR = 7.034, 95% CI, 2 = 54.399). Furthermore, we found A allele was significantly associated with increased risk of HCC, compared with G allele (2 = 53.034, OR-95% CI = 0.134 - 7.469). No such significant difference was found for cytokines (IL-1β and IL-10). Conclusion: Our study showed that TNF-α−308 G > A polymorphism was associated with increased HCC risk in Egypt population

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